Thimet Oligopeptidase (EC 3.4.24.15) Key Functions Suggested by Knockout Mice Phenotype Characterization

Thimet Oligopeptidase (EC 3.4.24.15) Key Functions Suggested by Knockout Mice Phenotype Characterization

Thimet oligopeptidase (THOP1) is thought to be involved in neuropeptide metabolism, antigen presentation, neurodegeneration, and cancer. Herein, the generation of THOP1 C57BL/6 knockout mice (THOP1<sup>&#8722;/&#8722;</sup>) is described showing that they are viable, have estrus...

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Bibliographic Details
Main Authors: Nilton B. dos Santos, Roseane D. Franco, Rosana Camarini, Carolina D. Munhoz, Rosangela A. S. Eichler, Mayara C. F. Gewehr, Patricia Reckziegel, Ricardo P. Llanos, Camila S. Dale, Victoria R. O. da Silva, Vanessa F. Borges, Braulio H. F. Lima, Fernando Q. Cunha, Bruna Visniauskas, Jair R. Chagas, Sergio Tufik, Fernanda F. Peres, Vanessa C. Abilio, Jorge C. Florio, Leo K. Iwai, Vanessa Rioli, Benedito C. Presoto, Alessander O. Guimaraes, Joao B. Pesquero, Michael Bader, Leandro M. Castro, Emer S. Ferro
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Biomolecules
Subjects:
THOP1
neurodegeneration
inflammation
sepsis
MHC-I
peptidome
Online Access:https://www.mdpi.com/2218-273X/9/8/382

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https://www.mdpi.com/2218-273X/9/8/382

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