<i>CUL4A</i>, <i>ERCC5</i>, and <i>ERCC1</i> as Predictive Factors for Trabectedin Efficacy in Advanced Soft Tissue Sarcomas (STS): A Spanish Group for Sarcoma Research (GEIS) Study

<i>CUL4A</i>, <i>ERCC5</i>, and <i>ERCC1</i> as Predictive Factors for Trabectedin Efficacy in Advanced Soft Tissue Sarcomas (STS): A Spanish Group for Sarcoma Research (GEIS) Study

A translational study was designed to analyze the expression of nucleotide excision repair (NER) and homologous recombination (HR) genes as potential predictive biomarkers for trabectedin in soft-tissue sarcoma (STS). This study is part of a randomized phase II trial comparing trabectedin plus doxor...

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Bibliographic Details
Main Authors: David S. Moura, Paloma Sanchez-Bustos, Antonio Fernandez-Serra, María Lopez-Alvarez, José L. Mondaza-Hernandez, Elena Blanco-Alcaina, Angela Gavilan-Naranjo, Paula Martinez-Delgado, Serena Lacerenza, Paloma Santos-Fernandez, Irene Carrasco-Garcia, Samuel Hidalgo-Rios, Antonio Gutierrez, Rafael Ramos, Nadia Hindi, Miguel Taron, Jose Antonio Lopez-Guerrero, Javier Martin-Broto
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
trabectedin
ERCC1
CUL4A
predictive biomarkers
soft-tissue sarcoma
Online Access:https://www.mdpi.com/2072-6694/12/5/1128

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https://www.mdpi.com/2072-6694/12/5/1128

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