Hepatotoxicity Induced by Sophora flavescens and Hepatic Accumulation of Kurarinone, a Major Hepatotoxic Constituent of Sophora flavescens in Rats

Hepatotoxicity Induced by Sophora flavescens and Hepatic Accumulation of Kurarinone, a Major Hepatotoxic Constituent of Sophora flavescens in Rats

Our previous study showed that kurarinone was the main hepatotoxic ingredient of Sophora flavescens, accumulating in the liver. This study characterized the mechanism of Sophora flavescens extract (ESF) hepatotoxicity and hepatic accumulation of kurarinone. ESF impaired hepatic function and caused f...

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Bibliographic Details
Main Authors: Peng Jiang, Xiuwen Zhang, Yutong Huang, Nengneng Cheng, Yueming Ma
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:Molecules
Subjects:
Sophora flavescens
kurarinone
hepatotoxicity
metabolomics
steatosis
transporter
Online Access:https://www.mdpi.com/1420-3049/22/11/1809

Internet

https://www.mdpi.com/1420-3049/22/11/1809

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