Angiotensin II promotes ovarian cancer spheroid formation and metastasis by upregulation of lipid desaturation and suppression of endoplasmic reticulum stress

Angiotensin II promotes ovarian cancer spheroid formation and metastasis by upregulation of lipid desaturation and suppression of endoplasmic reticulum stress

Abstract Background Angiotensin II (ANGII) and its receptor (AGTR1) have been proposed as significant contributors to metastasis in multiple cancers. Further, high AGTR1 levels are associated with poor epithelial ovarian cancer (EOC) outcomes. However, the mechanistic basis for these effects is unkn...

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Bibliographic Details
Main Authors: Qingyu Zhang, Shan Yu, Melody Man Ting Lam, Terence Chuen Wai Poon, Litao Sun, Yufei Jiao, Alice Sze Tsai Wong, Leo Tsz On Lee
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Angiotensin II
Ovarian cancer
Spheroid formation
Lipogenesis
Endoplasmic reticulum stress
Online Access:http://link.springer.com/article/10.1186/s13046-019-1127-x

Internet

http://link.springer.com/article/10.1186/s13046-019-1127-x

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