WWP1 knockout in mice exacerbates obesity‐related phenotypes in white adipose tissue but improves whole‐body glucose metabolism

WWP1 knockout in mice exacerbates obesity‐related phenotypes in white adipose tissue but improves whole‐body glucose metabolism

White adipose tissue (WAT) is important for maintenance of homeostasis, because it stores energy and secretes adipokines. The WAT of obese people demonstrates mitochondrial dysfunction, accompanied by oxidative stress, which leads to insulin resistance. WW domain‐containing E3 ubiquitin protein liga...

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Bibliographic Details
Main Authors: Shunsuke Hoshino, Masaki Kobayashi, Ryoma Tagawa, Ryutaro Konno, Takuro Abe, Kazuhiro Furuya, Kumi Miura, Hiroki Wakasawa, Naoyuki Okita, Yuka Sudo, Yuhei Mizunoe, Yoshimi Nakagawa, Takeshi Nakamura, Hiroshi Kawabe, Yoshikazu Higami
Format: Article
Language:English
Published: Wiley 2020-03-01
Series:FEBS Open Bio
Subjects:
white adipose tissue
obesity
WWP1
antioxidative capacity
mitochondrial function
Online Access:https://doi.org/10.1002/2211-5463.12795

Internet

https://doi.org/10.1002/2211-5463.12795

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