SpoT Induces Intracellular Salmonella Virulence Programs in the Phagosome

SpoT Induces Intracellular Salmonella Virulence Programs in the Phagosome

Pathogenic bacteria experience nutritional challenges during colonization and infection of mammalian hosts. Binding of the alarmone nucleotide guanosine tetraphosphate (ppGpp) to RNA polymerase coordinates metabolic adaptations and virulence gene transcription, increasing the fitness of diverse Gram...

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Bibliographic Details
Main Authors: Liam F. Fitzsimmons, Lin Liu, Sashi Kant, Ju-Sim Kim, James K. Till, Jessica Jones-Carson, Steffen Porwollik, Michael McClelland, Andres Vazquez-Torres
Format: Article
Language:English
Published: American Society for Microbiology 2020-02-01
Series:mBio
Subjects:
salmonella
bacterial pathogenesis
genetics
innate immunity
macrophages
stringent response
transposons
Online Access:https://doi.org/10.1128/mBio.03397-19

Internet

https://doi.org/10.1128/mBio.03397-19

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