TINF2 is a haploinsufficient tumor suppressor that limits telomere length

TINF2 is a haploinsufficient tumor suppressor that limits telomere length

Telomere shortening is a presumed tumor suppressor pathway that imposes a proliferative barrier (the Hayflick limit) during tumorigenesis. This model predicts that excessively long somatic telomeres predispose to cancer. Here, we describe cancer-prone families with two unique TINF2 mutations that tr...

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Bibliographic Details
Main Authors: Isabelle Schmutz, Arjen R Mensenkamp, Kaori K Takai, Maaike Haadsma, Liesbeth Spruijt, Richarda M de Voer, Seunga Sara Choo, Franziska K Lorbeer, Emma J van Grinsven, Dirk Hockemeyer, Marjolijn CJ Jongmans, Titia de Lange
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
cancer predisposition
TIN2
telomere length
Online Access:https://elifesciences.org/articles/61235

Internet

https://elifesciences.org/articles/61235

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