The Prophylactic Effect of Pinocembrin Against Doxorubicin-Induced Cardiotoxicity in an In Vitro H9c2 Cell Model

The Prophylactic Effect of Pinocembrin Against Doxorubicin-Induced Cardiotoxicity in an In Vitro H9c2 Cell Model

BackgroundThe clinical use of Doxorubicin (Dox) is significantly limited by its dose-dependent cardiotoxic side effect. Accumulative evidence suggests that the use of flavonoids, such as the antioxidative Pinocembrin (Pin), could be effective in the prevention of Dox-induced cardiotoxicity. Accordin...

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Bibliographic Details
Main Authors: Nonhlakanipho F. Sangweni, Malebogo Moremane, Sylvia Riedel, Derick van Vuuren, Barbara Huisamen, Lawrence Mabasa, Reenen Barry, Rabia Johnson
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Pharmacology
Subjects:
doxorubicin
cardiotoxicity
pinocembrin
antioxidants
mitochondrial bioenergetics
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01172/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.01172/full

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