Identification of Chalcone Derivatives as Inhibitors of Leishmania infantum Arginase and Promising Antileishmanial Agents

Identification of Chalcone Derivatives as Inhibitors of Leishmania infantum Arginase and Promising Antileishmanial Agents

Arginase catalyzes the hydrolysis of l-arginine into l-ornithine and urea, acting as a key enzyme in the biosynthesis of polyamines. Leishmania growth and survival is dependent on polyamine biosynthesis; therefore, inhibition of Leishmania arginase may be a promising therapeutic strategy. Here, we e...

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Bibliographic Details
Main Authors: Andreza R. Garcia, Danielle M. P. Oliveira, Jessica B. Jesus, Alessandra M. T. Souza, Ana Carolina R. Sodero, Alane B. Vermelho, Ivana C. R. Leal, Rodrigo Octavio M. A. Souza, Leandro S. M. Miranda, Anderson S. Pinheiro, Igor A. Rodrigues
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Chemistry
Subjects:
Leishmania infantum
arginase
inhibition
chalcone
antileishmanial activity
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2020.624678/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2020.624678/full

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