Binding of Phage-Encoded FlaGrab to Motile Campylobacter jejuni Flagella Inhibits Growth, Downregulates Energy Metabolism, and Requires Specific Flagellar Glycans

Binding of Phage-Encoded FlaGrab to Motile Campylobacter jejuni Flagella Inhibits Growth, Downregulates Energy Metabolism, and Requires Specific Flagellar Glycans

Many bacterial pathogens display glycosylated surface structures that contribute to virulence, and targeting these structures is a viable strategy for pathogen control. The foodborne pathogen Campylobacter jejuni expresses a vast diversity of flagellar glycans, and flagellar glycosylation is essenti...

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Bibliographic Details
Main Authors: Jessica C. Sacher, Asif Shajahan, James Butcher, Robert T. Patry, Annika Flint, David R. Hendrixson, Alain Stintzi, Parastoo Azadi, Christine M. Szymanski
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Microbiology
Subjects:
bacteriophages
Campylobacter jejuni
flagella
protein glycosylation
pseudaminic acid
mass spectrometry
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00397/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.00397/full

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