Eplerenone Implantation Improved Adipose Dysfunction Averting RAAS Activation and Cell Division

Eplerenone Implantation Improved Adipose Dysfunction Averting RAAS Activation and Cell Division

Introduction: Mineralocorticoid receptor (MR) activation within adipose tissue, triggers inflammation and metabolic syndrome development. The pharmacological blockade of MR provides beneficial effects for adipose tissue. Our study evaluates the impact of eplerenone implantation upon obesity.Experime...

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Bibliographic Details
Main Authors: Andrea Vecchiola, Cristóbal A. Fuentes, Isidora Solar, Carlos F. Lagos, Maria Cecilia Opazo, Natalia Muñoz-Durango, Claudia A. Riedel, Gareth I. Owen, Alexis M. Kalergis, Carlos E. Fardella
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Endocrinology
Subjects:
obesity
aldosterone
mineralocorticoid receptor
MR antagonists
eplerenone
high-fat diet animal model
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00223/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2020.00223/full

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