Genetic Variation in Low-To-Medium-Affinity Fcγ Receptors: Functional Consequences, Disease Associations, and Opportunities for Personalized Medicine

Genetic Variation in Low-To-Medium-Affinity Fcγ Receptors: Functional Consequences, Disease Associations, and Opportunities for Personalized Medicine

Fc-gamma receptors (FcγR) are the cellular receptors for Immunoglobulin G (IgG). Upon binding of complexed IgG, FcγRs can trigger various cellular immune effector functions, thereby linking the adaptive and innate immune systems. In humans, six classic FcγRs are known: one high-affinity receptor (Fc...

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Bibliographic Details
Main Authors: Sietse Q. Nagelkerke, David E. Schmidt, Masja de Haas, Taco W. Kuijpers
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
Fc gamma receptor (FcγR)
genetic variation
autoinflammatory and autoimmune diseases
immunotherapy
mechanisms of disease
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02237/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02237/full

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