Macrophage Activation in the Synovium of Healthy and Osteoarthritic Equine Joints

Macrophage Activation in the Synovium of Healthy and Osteoarthritic Equine Joints

Synovitis is a major component of osteoarthritis and is driven primarily by macrophages. Synovial macrophages are crucial for joint homeostasis (M2-like phenotype), but induce inflammation (M1-like) when regulatory functions become overwhelmed. Macrophage phenotypes in synovium from osteoarthritic a...

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Bibliographic Details
Main Authors: Bruno C. Menarim, Kiersten H. Gillis, Andrea Oliver, Ying Ngo, Stephen R. Werre, Sarah H. Barrett, Dwayne H. Rodgerson, Linda A. Dahlgren
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Veterinary Science
Subjects:
joint homeostasis
osteoarthiritis
synovitis
inflammatioin
activation
polarization
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2020.568756/full

Internet

https://www.frontiersin.org/articles/10.3389/fvets.2020.568756/full

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