Controlling T cells spreading, mechanics and activation by micropatterning

Abstract We designed a strategy, based on a careful examination of the activation capabilities of proteins and antibodies used as substrates for adhering T cells, coupled to protein microstamping to control at the same time the position, shape, spreading, mechanics and activation state of T cells. O...

Full description

Bibliographic Details
Main Authors: Anaïs Sadoun, Martine Biarnes-Pelicot, Laura Ghesquiere-Dierickx, Ambroise Wu, Olivier Théodoly, Laurent Limozin, Yannick Hamon, Pierre-Henri Puech
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-86133-1