Clostridial C3 Toxins Enter and Intoxicate Human Dendritic Cells

Clostridial C3 Toxins Enter and Intoxicate Human Dendritic Cells

C3 protein toxins produced by <i>Clostridium (C.) botulinum</i> and <i>C. limosum</i> are mono-ADP-ribosyltransferases, which specifically modify the GTPases Rho A/B/C in the cytosol of monocytic cells, thereby inhibiting Rho-mediated signal transduction in monocytes, macroph...

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Bibliographic Details
Main Authors: Maximilian Fellermann, Christina Huchler, Lea Fechter, Tobias Kolb, Fanny Wondany, Daniel Mayer, Jens Michaelis, Steffen Stenger, Kevin Mellert, Peter Möller, Thomas F. E. Barth, Stephan Fischer, Holger Barth
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Toxins
Subjects:
dendritic cells
clostridial C3 toxins
cellular uptake
C3bot<sub>E174Q</sub>
fusion toxin C2IN-C3lim
stimulated emission depletion (STED)
Online Access:https://www.mdpi.com/2072-6651/12/9/563

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https://www.mdpi.com/2072-6651/12/9/563

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