A validated LC-MS/MS assay for quantification of 24(S)-hydroxycholesterol in plasma and cerebrospinal fluid

A validated LC-MS/MS assay for quantification of 24(S)-hydroxycholesterol in plasma and cerebrospinal fluid

24(S)-hydroxycholesterol [24(S)-HC] is a cholesterol metabolite that is formed almost exclusively in the brain. The concentrations of 24(S)-HC in cerebrospinal fluid (CSF) and/or plasma might be a sensitive marker of altered cholesterol metabolism in the CNS. A highly sensitive 2D-LC-MS/MS assay was...

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Bibliographic Details
Main Authors: Rohini Sidhu, Hui Jiang, Nicole Y. Farhat, Nuria Carrillo-Carrasco, Myra Woolery, Elizabeth Ottinger, Forbes D. Porter, Jean E. Schaffer, Daniel S. Ory, Xuntian Jiang
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Journal of Lipid Research
Subjects:
two-dimensional liquid chromatography-tandem mass spectrometry
validation
Niemann-Pick C1 disease
2-hydroxypropyl-β-cyclodextrin
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520317326

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http://www.sciencedirect.com/science/article/pii/S0022227520317326

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