BIM-mediated AKT phosphorylation is a key modulator of arsenic trioxide-induced apoptosis in cisplatin-sensitive and -resistant ovarian cancer cells.

BIM-mediated AKT phosphorylation is a key modulator of arsenic trioxide-induced apoptosis in cisplatin-sensitive and -resistant ovarian cancer cells.

Chemo-resistance to cisplatin-centered cancer therapy is a major obstacle to the effective treatment of human ovarian cancer. Previous reports indicated that arsenic trioxide (ATO) induces cell apoptosis in both drug-sensitive and -resistant ovarian cancer cells.In this study, we determined the mole...

Full description

Bibliographic Details
Main Authors: Zhu Yuan, Fang Wang, Zhiwei Zhao, Xinyu Zhao, Ji Qiu, Chunlai Nie, Yuquan Wei
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3105099?pdf=render

Internet

http://europepmc.org/articles/PMC3105099?pdf=render

Similar Items