Zinc Depletion by TPEN Induces Apoptosis in Human Acute Promyelocytic NB4 Cells

Zinc Depletion by TPEN Induces Apoptosis in Human Acute Promyelocytic NB4 Cells

Background/Aims: The effects of zinc signaling on proliferation or apoptosis of leukemia cells remain elusive. In the present study, we used N, N, N’, N’-tetrakis-(2-pyridylmethyl)-ethylene-diamine (TPEN), a membrane-permeable zinc chelator, to evaluate the effect of zinc depletion on survival and a...

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Bibliographic Details
Main Authors: Bo Zhu, Jiayu Wang, Feng Zhou, Yingting Liu, Yueyang Lai, Jie Wang, Xiao Chen, Dianhua Chen, Lan Luo, Zi-Chun Hua
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
TPEN
Zinc
Nitric oxide
Apoptosis
Acute promyelocytic leukemia
Online Access:http://www.karger.com/Article/FullText/479539

Internet

http://www.karger.com/Article/FullText/479539

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