Loss of stearoyl-CoA desaturase 1 rescues cardiac function in obese leptin-deficient mice

Loss of stearoyl-CoA desaturase 1 rescues cardiac function in obese leptin-deficient mice

The heart of leptin-deficient ob/ob mice is characterized by pathologic left ventricular hypertrophy along with elevated triglyceride (TG) content, increased stearoyl-CoA desaturase (SCD) activity, and increased myocyte apoptosis. In the present study, using an ob/ob;SCD1−/− mouse model, we tested t...

Full description

Bibliographic Details
Main Authors: Pawel Dobrzyn, Agnieszka Dobrzyn, Makoto Miyazaki, James M. Ntambi
Format: Article
Language:English
Published: Elsevier 2010-08-01
Series:Journal of Lipid Research
Subjects:
heart steatosis
apoptosis
ceramide
leptin
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520370565

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520370565

Similar Items