Mitochondria supply ATP to the ER through a mechanism antagonized by cytosolic Ca2+

Mitochondria supply ATP to the ER through a mechanism antagonized by cytosolic Ca2+

The endoplasmic reticulum (ER) imports ATP and uses energy from ATP hydrolysis for protein folding and trafficking. However, little is known about how this vital ATP transport occurs across the ER membrane. Here, using three commonly used cell lines (CHO, INS1 and HeLa), we report that ATP enters th...

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Bibliographic Details
Main Authors: Jing Yong, Helmut Bischof, Sandra Burgstaller, Marina Siirin, Anne Murphy, Roland Malli, Randal J Kaufman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-09-01
Series:eLife
Subjects:
ER stress
ATP and adenosine nucleotides transport
organelle bioenergetics
protein folding
Chinese hamster ovary cell
SLC35B1/AXER protein
Online Access:https://elifesciences.org/articles/49682

Internet

https://elifesciences.org/articles/49682

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