LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice[S]

LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice[S]

The liver X receptor (LXR) signaling pathway is an important modulator of atherosclerosis, but the relative importance of the two LXRs in atheroprotection is incompletely understood. We show here that LXRα, the dominant LXR isotype expressed in liver, plays a particularly important role in whole-bod...

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Bibliographic Details
Main Authors: Cynthia Hong, Michele N. Bradley, Xin Rong, Xuping Wang, Alan Wagner, Victor Grijalva, Lawrence W. Castellani, Jon Salazar, Susan Realegeno, Rima Boyadjian, Alan M. Fogelman, Brian J. Van Lenten, Srinivasa T. Reddy, Aldons J. Lusis, Rajendra K. Tangirala, Peter Tontonoz
Format: Article
Language:English
Published: Elsevier 2012-06-01
Series:Journal of Lipid Research
Subjects:
atherosclerosis
nuclear receptor
cholesterol metabolism
apoliporotein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520317053

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http://www.sciencedirect.com/science/article/pii/S0022227520317053

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