PDCD4 Knockdown Induces Senescence in Hepatoma Cells by Up-Regulating the p21 Expression

PDCD4 Knockdown Induces Senescence in Hepatoma Cells by Up-Regulating the p21 Expression

While the over-expression of tumor suppressor programmed cell death 4 (PDCD4) induces apoptosis, it was recently shown that PDCD4 knockdown also induced apoptosis. In this study, we examined the cell cycle regulators whose activation is affected by PDCD4 knockdown to investigate the contribution of...

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Bibliographic Details
Main Authors: Jing Guo, Iwata Ozaki, Jinghe Xia, Takuya Kuwashiro, Motoyasu Kojima, Hirokazu Takahashi, Kenji Ashida, Keizo Anzai, Sachiko Matsuhashi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Oncology
Subjects:
PDCD4
p21
senescence
apoptosis
hepatoma cells
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00661/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2018.00661/full

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