Germline burden of rare damaging variants negatively affects human healthspan and lifespan

Germline burden of rare damaging variants negatively affects human healthspan and lifespan

Heritability of human lifespan is 23–33% as evident from twin studies. Genome-wide association studies explored this question by linking particular alleles to lifespan traits. However, genetic variants identified so far can explain only a small fraction of lifespan heritability in humans. Here, we r...

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Bibliographic Details
Main Authors: Anastasia V Shindyapina, Aleksandr A Zenin, Andrei E Tarkhov, Didac Santesmasses, Peter O Fedichev, Vadim N Gladyshev
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-04-01
Series:eLife
Subjects:
lifespan
healthspan
aging
mutation
Online Access:https://elifesciences.org/articles/53449

Internet

https://elifesciences.org/articles/53449

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