Positive Effects of NPY1 Receptor Activation on Islet Structure Are Driven by Pancreatic Alpha- and Beta-Cell Transdifferentiation in Diabetic Mice

Positive Effects of NPY1 Receptor Activation on Islet Structure Are Driven by Pancreatic Alpha- and Beta-Cell Transdifferentiation in Diabetic Mice

Enzymatically stable and specific neuropeptide Y1 receptor (NPYR1) agonists, such as sea lamprey PYY(1-36) (SL-PYY(1-36)), are believed to improve glucose regulation in diabetes by targeting pancreatic islets. In this study, streptozotocin (STZ) diabetic transgenic GluCreERT2;ROSA26-eYFP and Ins1Cre...

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Bibliographic Details
Main Authors: Ryan A. Lafferty, Neil Tanday, R. Charlotte Moffett, Frank Reimann, Fiona M. Gribble, Peter R. Flatt, Nigel Irwin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Endocrinology
Subjects:
peptide YY
sea lamprey PYY
diabetes
transdifferentiation
streptozotocin
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.633625/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2021.633625/full

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