MicroRNA-425 and microRNA-155 cooperatively regulate atrial natriuretic peptide expression and cGMP production.

MicroRNA-425 and microRNA-155 cooperatively regulate atrial natriuretic peptide expression and cGMP production.

AIMS:Atrial natriuretic peptide (ANP), secreted primarily by atrial cardiomyocytes, decreases blood pressure by raising cyclic 3',5'-guanosine monophosphate (cGMP) levels and inducing vasorelaxation, natriuresis, and diuresis. Raising the level of ANP has been shown to be an effective trea...

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Bibliographic Details
Main Authors: Sara Vandenwijngaert, Clara D Ledsky, Obiajulu Agha, Connie Wu, Dongjian Hu, Aranya Bagchi, Ibrahim J Domian, Emmanuel S Buys, Christopher Newton-Cheh, Donald B Bloch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5919659?pdf=render

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http://europepmc.org/articles/PMC5919659?pdf=render

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