Congenic mapping and allele-specific alteration analysis of Stmm1 locus conferring resistance to early-stage chemically induced skin papillomas.

Genome-wide association studies have revealed that many low-penetrance cancer susceptibility loci are located throughout the genome; however, a very limited number of genes have been identified so far. Using a forward genetics approach to map such loci in a mouse skin cancer model, we previously ide...

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Bibliographic Details
Main Authors: Kazuhiro Okumura, Megumi Saito, Eriko Isogai, Ikuo Miura, Shigeharu Wakana, Ryo Kominami, Yuichi Wakabayashi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4028187?pdf=render