Alterations of pancreatic islet structure, metabolism and gene expression in diet-induced obese C57BL/6J mice.

Alterations of pancreatic islet structure, metabolism and gene expression in diet-induced obese C57BL/6J mice.

The reduction of functional β cell mass is a key feature of type 2 diabetes. Here, we studied metabolic functions and islet gene expression profiles of C57BL/6J mice with naturally occurring nicotinamide nucleotide transhydrogenase (NNT) deletion mutation, a widely used model of diet-induced obesity...

Full description

Bibliographic Details
Main Authors: Regan Roat, Vandana Rao, Nicolai M Doliba, Franz M Matschinsky, John W Tobias, Eden Garcia, Rexford S Ahima, Yumi Imai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3914796?pdf=render

Internet

http://europepmc.org/articles/PMC3914796?pdf=render

Similar Items