Alterations of pancreatic islet structure, metabolism and gene expression in diet-induced obese C57BL/6J mice.
The reduction of functional β cell mass is a key feature of type 2 diabetes. Here, we studied metabolic functions and islet gene expression profiles of C57BL/6J mice with naturally occurring nicotinamide nucleotide transhydrogenase (NNT) deletion mutation, a widely used model of diet-induced obesity...
Main Authors: | Regan Roat, Vandana Rao, Nicolai M Doliba, Franz M Matschinsky, John W Tobias, Eden Garcia, Rexford S Ahima, Yumi Imai |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3914796?pdf=render |
Similar Items
-
Inhibition of cholinergic potentiation of insulin secretion from pancreatic islets by chronic elevation of glucose and fatty acids: Protection by casein kinase 2 inhibitor
by: Nicolai M. Doliba, et al.
Published: (2017-10-01) -
Data on morphometric analysis of the pancreatic islets from C57BL/6 and BALB/c mice
by: Thiago Aparecido da Silva, et al.
Published: (2016-09-01) -
Analyzing whether prevascularizing islet scaffolds improves islet survival in C57 BL/6 mouse models
by: Erdman, Dan
Published: (2020) -
Dual Opposing Roles of Metallothionein Overexpression in C57BL/6J Mouse Pancreatic β-Cells.
by: Suqin Chen, et al.
Published: (2015-01-01) -
The feeding pattern of C57BL/6J mice
by: Rathod, Yakshkumar Dilipbhai
Published: (2020)