WDHD1 Leads to Cisplatin Resistance by Promoting MAPRE2 Ubiquitination in Lung Adenocarcinoma

WDHD1 Leads to Cisplatin Resistance by Promoting MAPRE2 Ubiquitination in Lung Adenocarcinoma

Ubiquitin ligases have been shown to regulate drug sensitivity. This study aimed to explore the role of the ubiquitin ligase WD repeat and HMG-box DNA binding protein 1 (WDHD1) in regulating cisplatin sensitivity in lung adenocarcinoma (LUAD). A quantitative analysis of the global proteome identifie...

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Bibliographic Details
Main Authors: Lian Gong, Mengqing Xiao, Dong He, Yi Hu, Yuxing Zhu, Liang Xiang, Ying Bao, Xiaoming Liu, Qinghai Zeng, Jianye Liu, Ming Zhou, Yanhong Zhou, Yaxin Cheng, Yeyu Zhang, Liping Deng, Rongrong Zhu, Hua Lan, Ke Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Oncology
Subjects:
lung adenocarcinoma
cisplatin
drug sensitivity
ubiquitin ligase
WDHD1
MAPRE2
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00461/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00461/full

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