Modulation of Immunogenicity and Conformation of HA1 Subunit of Influenza A Virus H1/N1 Hemagglutinin in Tubular Immunostimulating Complexes

Modulation of Immunogenicity and Conformation of HA1 Subunit of Influenza A Virus H1/N1 Hemagglutinin in Tubular Immunostimulating Complexes

The HA1 subunit of the influenza virus hemagglutinin (HA) is a valuable antigen for the development of vaccines against flu due to the availability of most antigenic sites which are conformational. Therefore, a novel adjuvanted antigen delivery system, tubular immunostimulating complexes (TI-complex...

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Bibliographic Details
Main Authors: Nina Sanina, Ludmila Davydova, Natalia Chopenko, Eduard Kostetsky, Valery Shnyrov
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:International Journal of Molecular Sciences
Subjects:
TI-complex
adjuvant
antigen delivery system
monogalactosyldiacylglycerol
lipid-induced protein conformation
DSC
intrinsic fluorescence
vaccines
Online Access:https://www.mdpi.com/1422-0067/18/9/1895

Internet

https://www.mdpi.com/1422-0067/18/9/1895

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