Phosphorylation of Glutamine Synthetase on Threonine 301 Contributes to Its Inactivation During Epilepsy

Phosphorylation of Glutamine Synthetase on Threonine 301 Contributes to Its Inactivation During Epilepsy

The astrocyte-specific enzyme glutamine synthetase (GS), which catalyzes the amidation of glutamate to glutamine, plays an essential role in supporting neurotransmission and in limiting NH4+ toxicity. Accordingly, deficits in GS activity contribute to epilepsy and neurodegeneration. Despite its cent...

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Bibliographic Details
Main Authors: Deborah Huyghe, Andrew R. Denninger, Caroline M. Voss, Pernille Frank, Ning Gao, Nicholas Brandon, Helle S. Waagepetersen, Andrew D. Ferguson, Menelas Pangalos, Peter Doig, Stephen J. Moss
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
glutamine synthetase
phosphorylation
epilepsy
astrocyte
cAMP-dependent protein kinase
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00120/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00120/full

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