Development of a Drug-Response Modeling Framework to Identify Cell Line Derived Translational Biomarkers That Can Predict Treatment Outcome to Erlotinib or Sorafenib.

Development of a Drug-Response Modeling Framework to Identify Cell Line Derived Translational Biomarkers That Can Predict Treatment Outcome to Erlotinib or Sorafenib.

Development of drug responsive biomarkers from pre-clinical data is a critical step in drug discovery, as it enables patient stratification in clinical trial design. Such translational biomarkers can be validated in early clinical trial phases and utilized as a patient inclusion parameter in later s...

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Bibliographic Details
Main Authors: Bin Li, Hyunjin Shin, Georgy Gulbekyan, Olga Pustovalova, Yuri Nikolsky, Andrew Hope, Marina Bessarabova, Matthew Schu, Elona Kolpakova-Hart, David Merberg, Andrew Dorner, William L Trepicchio
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4480971?pdf=render

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http://europepmc.org/articles/PMC4480971?pdf=render

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