FBXO2 modulates STAT3 signaling to regulate proliferation and tumorigenicity of osteosarcoma cells

FBXO2 modulates STAT3 signaling to regulate proliferation and tumorigenicity of osteosarcoma cells

Abstract Background Osteosarcoma (OS) is the most common primary bone malignancy in children and adolescents, and hyperproliferation of cells is a major problem of OS. FBXO2 belongs to the family of F-box proteins, and is a substrate recognition component of the Skp1-Cul1-F-box protein (SCF) E3 ubiq...

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Bibliographic Details
Main Authors: Xunming Zhao, Weichun Guo, Lixue Zou, Biao Hu
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Cancer Cell International
Subjects:
Osteosarcoma
FBXO2
STAT3
IL-6R
Degradation
Online Access:http://link.springer.com/article/10.1186/s12935-020-01326-4

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http://link.springer.com/article/10.1186/s12935-020-01326-4

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