Influence of Kartogenin on Chondrogenic Differentiation of Human Bone Marrow-Derived MSCs in 2D Culture and in Co-Cultivation with OA Osteochondral Explant

Influence of Kartogenin on Chondrogenic Differentiation of Human Bone Marrow-Derived MSCs in 2D Culture and in Co-Cultivation with OA Osteochondral Explant

Articular cartilage has limited capacity for natural regeneration and repair. In the present study, we evaluated kartogenin (KGN), a bioactive small heterocyclic molecule, for its effect on in vitro proliferation and chondrogenic differentiation of human bone marrow-derived mesenchymal stromal cells...

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Bibliographic Details
Main Authors: Timea Spakova, Jana Plsikova, Denisa Harvanova, Marek Lacko, Stefan Stolfa, Jan Rosocha
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Molecules
Subjects:
kartogenin
mesenchymal stromal cells
osteochondral cylinder
osteoarthritis
chondrogenic differentiation
Online Access:http://www.mdpi.com/1420-3049/23/1/181

Internet

http://www.mdpi.com/1420-3049/23/1/181

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