Concerted regulation of ISWI by an autoinhibitory domain and the H4 N-terminal tail

Concerted regulation of ISWI by an autoinhibitory domain and the H4 N-terminal tail

ISWI-family nucleosome remodeling enzymes need the histone H4 N-terminal tail to mobilize nucleosomes. Here we mapped the H4-tail binding pocket of ISWI. Surprisingly the binding site was adjacent to but not overlapping with the docking site of an auto-regulatory motif, AutoN, in the N-terminal regi...

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Bibliographic Details
Main Authors: Johanna Ludwigsen, Sabrina Pfennig, Ashish K Singh, Christina Schindler, Nadine Harrer, Ignasi Forné, Martin Zacharias, Felix Mueller-Planitz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-01-01
Series:eLife
Subjects:
chromatin remodeling
nucleosome
ATPase
Snf2
Online Access:https://elifesciences.org/articles/21477

Internet

https://elifesciences.org/articles/21477

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