Defining the molecular mechanisms of the mitochondrial permeability transition through genetic manipulation of F-ATP synthase

Defining the molecular mechanisms of the mitochondrial permeability transition through genetic manipulation of F-ATP synthase

The nature of the mitochondrial permeability transition pore (PTP) is still under debate. Here, through genetically modified F-ATP synthase, the authors show that PTP formation can be mediated by F-ATP synthase or by adenine nucleotide translocator, suggesting the existence of distinct but related p...

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Bibliographic Details
Main Authors: Andrea Carrer, Ludovica Tommasin, Justina Šileikytė, Francesco Ciscato, Riccardo Filadi, Andrea Urbani, Michael Forte, Andrea Rasola, Ildikò Szabò, Michela Carraro, Paolo Bernardi
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25161-x

Internet

https://doi.org/10.1038/s41467-021-25161-x

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