Extracellular Degradation Into Adenosine and the Activities of Adenosine Kinase and AMPK Mediate Extracellular NAD+-Produced Increases in the Adenylate Pool of BV2 Microglia Under Basal Conditions

Extracellular Degradation Into Adenosine and the Activities of Adenosine Kinase and AMPK Mediate Extracellular NAD+-Produced Increases in the Adenylate Pool of BV2 Microglia Under Basal Conditions

Cumulating evidence has indicated NAD+ deficiency as a common central pathological factor of multiple diseases and aging. NAD+ supplement is highly protective in various disease and aging models, while two key questions have remained unanswered: (1) Does extracellular NAD+ also produce its effects t...

Full description

Bibliographic Details
Main Authors: Jie Zhang, Caixia Wang, Haibo Shi, Danhong Wu, Weihai Ying
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
NAD+
microglia
adenylate pool
adenosine
AMPK
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00343/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00343/full

Similar Items