How drug resistance takes shape

Mutations in a hormone receptor can lead to therapeutic resistance by making it less able to bind and respond to hormone blocking drugs and by making it active, even when the hormome is not present.

Bibliographic Details
Main Authors:	Rinath Jeselsohn, Myles Brown
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2016-03-01
Series:	eLife
Subjects:	breast cancer acquired drug resistance somatic mutation estrogen receptor alpha hormone selective estrogen receptor modulators
Online Access:	https://elifesciences.org/articles/14973

id	doaj-ff89928d93f34e25b9dd4cffd38a9e3c
record_format	Article
spelling	doaj-ff89928d93f34e25b9dd4cffd38a9e3c2021-05-05T00:19:49ZengeLife Sciences Publications LtdeLife2050-084X2016-03-01510.7554/eLife.14973How drug resistance takes shapeRinath Jeselsohn0Myles Brown1Center for Functional Cancer Epigenetics and the Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States; Department of Medicine, Harvard Medical School, Boston, United StatesCenter for Functional Cancer Epigenetics and the Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States; Department of Medicine, Harvard Medical School, Boston, United StatesMutations in a hormone receptor can lead to therapeutic resistance by making it less able to bind and respond to hormone blocking drugs and by making it active, even when the hormome is not present.https://elifesciences.org/articles/14973breast canceracquired drug resistancesomatic mutationestrogen receptor alphahormoneselective estrogen receptor modulators
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Rinath Jeselsohn Myles Brown
spellingShingle	Rinath Jeselsohn Myles Brown How drug resistance takes shape eLife breast cancer acquired drug resistance somatic mutation estrogen receptor alpha hormone selective estrogen receptor modulators
author_facet	Rinath Jeselsohn Myles Brown
author_sort	Rinath Jeselsohn
title	How drug resistance takes shape
title_short	How drug resistance takes shape
title_full	How drug resistance takes shape
title_fullStr	How drug resistance takes shape
title_full_unstemmed	How drug resistance takes shape
title_sort	how drug resistance takes shape
publisher	eLife Sciences Publications Ltd
series	eLife
issn	2050-084X
publishDate	2016-03-01
description	Mutations in a hormone receptor can lead to therapeutic resistance by making it less able to bind and respond to hormone blocking drugs and by making it active, even when the hormome is not present.
topic	breast cancer acquired drug resistance somatic mutation estrogen receptor alpha hormone selective estrogen receptor modulators
url	https://elifesciences.org/articles/14973
work_keys_str_mv	AT rinathjeselsohn howdrugresistancetakesshape AT mylesbrown howdrugresistancetakesshape
_version_	1721476451252830208

How drug resistance takes shape

Similar Items