NaCl and KCl mediate log increase in AAV vector particles and infectious titers in a specific/timely manner with the HSV platform

The increasing demand for adeno-associated virus (AAV) vectors, a result from the surging interest for their potential to cure human genetic diseases by gene transfer, tumbled on low-performing production systems. Innovative improvements to increase both yield and quality of the vector produced have...

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Bibliographic Details
Main Authors: Chenghui Yu, Prasad D. Trivedi, Payel Chaudhuri, Radhika Bhake, Evan J. Johnson, Tina Caton, Mark Potter, Barry J. Byrne, Nathalie Clément
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
AAV
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121000309