Role of sex and high-fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer’s disease

Role of sex and high-fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer’s disease

Abstract Background Hypothalamic dysfunction occurs early in the clinical course of Alzheimer’s disease (AD), likely contributing to disturbances in feeding behavior and metabolic function that are often observed years prior to the onset of cognitive symptoms. Late-life weight loss and low BMI are a...

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Bibliographic Details
Main Authors: Lisa S. Robison, Olivia J. Gannon, Melissa A. Thomas, Abigail E. Salinero, Charly Abi-Ghanem, Yannick Poitelon, Sophie Belin, Kristen L. Zuloaga
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Journal of Neuroinflammation
Subjects:
Sex
Alzheimer’s disease
High-fat diet
Obesity
Inflammation
Diabetes
Online Access:http://link.springer.com/article/10.1186/s12974-020-01956-5

Internet

http://link.springer.com/article/10.1186/s12974-020-01956-5

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