Endothelial AMP-Activated Kinase α1 Phosphorylates eNOS on Thr495 and Decreases Endothelial NO Formation

Endothelial AMP-Activated Kinase α1 Phosphorylates eNOS on Thr495 and Decreases Endothelial NO Formation

AMP-activated protein kinase (AMPK) is frequently reported to phosphorylate Ser1177 of the endothelial nitric-oxide synthase (eNOS), and therefore, is linked with a relaxing effect. However, previous studies failed to consistently demonstrate a major role for AMPK on eNOS-dependent relaxation. As AM...

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Bibliographic Details
Main Authors: Nina Zippel, Annemarieke E. Loot, Heike Stingl, Voahanginirina Randriamboavonjy, Ingrid Fleming, Beate Fisslthaler
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:International Journal of Molecular Sciences
Subjects:
endothelial nitric-oxide synthase
vasodilation
phenylephrine
vasoconstriction
endothelial cells
ionomycin
Online Access:http://www.mdpi.com/1422-0067/19/9/2753

Internet

http://www.mdpi.com/1422-0067/19/9/2753

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