Dopamine induced neurodegeneration in a PINK1 model of Parkinson's disease.

BACKGROUND:Parkinson's disease is a common neurodegenerative disease characterised by progressive loss of dopaminergic neurons, leading to dopamine depletion in the striatum. Mutations in the PINK1 gene cause an autosomal recessive form of Parkinson's disease. Loss of PINK1 function causes...

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Bibliographic Details
Main Authors: Sonia Gandhi, Annika Vaarmann, Zhi Yao, Michael R Duchen, Nicholas W Wood, Andrey Y Abramov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3360782?pdf=render