Ormeloxifene-induced unfolded protein response contributes to autophagy-associated apoptosis via disruption of Akt/mTOR and activation of JNK

Ormeloxifene-induced unfolded protein response contributes to autophagy-associated apoptosis via disruption of Akt/mTOR and activation of JNK

Abstract Autophagy, a regulated nutrient recycling program can affect both cell survival and cell death. Here, we show that Ormeloxifene (ORM), a selective estrogen receptor modulator approved for oral contraceptive use induces autophagic flux in ovarian cancer cells, which is activated by an ER str...

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Bibliographic Details
Main Authors: Arindam Bhattacharjee, Mohammad Hasanain, Manoj Kathuria, Akhilesh Singh, Dipak Datta, Jayanta Sarkar, Kalyan Mitra
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-20541-8

Internet

https://doi.org/10.1038/s41598-018-20541-8

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