Soluble tau aggregates inhibit synaptic long-term depression and amyloid β-facilitated LTD in vivo

Soluble tau aggregates inhibit synaptic long-term depression and amyloid β-facilitated LTD in vivo

Soluble synaptotoxic aggregates of the main pathological proteins of Alzheimer's disease, amyloid β-protein (Aß) and tau, have rapid and potent inhibitory effects on long-term potentiation (LTP). Although the promotion of synaptic weakening mechanisms, including long-term depression (LTD), is p...

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Bibliographic Details
Main Authors: Tomas Ondrejcak, Neng-Wei Hu, Yingjie Qi, Igor Klyubin, Grant T. Corbett, Graham Fraser, Michael S. Perkinton, Dominic M. Walsh, Andrew Billinton, Michael J. Rowan
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Microtubule-associated protein tau
Amyloid β-protein
Synaptic plasticity
Rat hippocampus
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119300750

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http://www.sciencedirect.com/science/article/pii/S0969996119300750

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