Allele dependent silencing of COL1A2 using small interfering RNAs
<p>Osteogenesis imperfecta (OI) is generally caused by a dominant mutation in Collagen I, encoded by the genes <i>COL1A1</i> and<i> COL1A2</i>. To date there is no satisfactory therapy for OI, but inactivation of the mutant allele through small interfering RNAs (siRNA)...
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| Format: | Article |
| Language: | English |
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Ivyspring International Publisher
2008-01-01
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| Series: | International Journal of Medical Sciences |
| Online Access: | http://www.medsci.org/v05p0361.htm |