Expanding the Structural Diversity of DNA Methyltransferase Inhibitors

Expanding the Structural Diversity of DNA Methyltransferase Inhibitors

Inhibitors of DNA methyltransferases (DNMTs) are attractive compounds for epigenetic drug discovery. They are also chemical tools to understand the biochemistry of epigenetic processes. Herein, we report five distinct inhibitors of DNMT1 characterized in enzymatic inhibition assays that did not show...

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Bibliographic Details
Main Authors: K. Eurídice Juárez-Mercado, Fernando D. Prieto-Martínez, Norberto Sánchez-Cruz, Andrea Peña-Castillo, Diego Prada-Gracia, José L. Medina-Franco
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceuticals
Subjects:
dietary component
epigenetics
enzyme inhibition
focused library
epi-informatics
multitarget epigenetic agent
Online Access:https://www.mdpi.com/1424-8247/14/1/17

Internet

https://www.mdpi.com/1424-8247/14/1/17

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