Genotoxic stress-triggered β-catenin/JDP2/PRMT5 complex facilitates reestablishing glutathione homeostasis

Genotoxic stress-triggered β-catenin/JDP2/PRMT5 complex facilitates reestablishing glutathione homeostasis

It is known that genotoxic stress induces high levels of ROS and deplete cellular glutathione stores. Here, Cao et al. uncover a β-catenin-dependent TCF/LEF-independent mechanism that promotes histone-mediated transcriptional activation of glutathione synthesis.

Bibliographic Details
Main Authors: Lixue Cao, Geyan Wu, Jinrong Zhu, Zhanyao Tan, Dongni Shi, Xingui Wu, Miaoling Tang, Ziwen Li, Yameng Hu, Shuxia Zhang, Ruyuan Yu, Shuang Mo, Jueheng Wu, Erwei Song, Mengfeng Li, Libing Song, Jun Li
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11696-7

Internet

https://doi.org/10.1038/s41467-019-11696-7

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