Genotoxic stress-triggered β-catenin/JDP2/PRMT5 complex facilitates reestablishing glutathione homeostasis
It is known that genotoxic stress induces high levels of ROS and deplete cellular glutathione stores. Here, Cao et al. uncover a β-catenin-dependent TCF/LEF-independent mechanism that promotes histone-mediated transcriptional activation of glutathione synthesis.
Main Authors: | Lixue Cao, Geyan Wu, Jinrong Zhu, Zhanyao Tan, Dongni Shi, Xingui Wu, Miaoling Tang, Ziwen Li, Yameng Hu, Shuxia Zhang, Ruyuan Yu, Shuang Mo, Jueheng Wu, Erwei Song, Mengfeng Li, Libing Song, Jun Li |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-08-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-11696-7 |
Similar Items
-
NKX2-8 deletion-induced reprogramming of fatty acid metabolism confers chemoresistance in epithelial ovarian cancerResearch in context
by: Jinrong Zhu, et al.
Published: (2019-05-01) -
Antagonizing miR-455-3p inhibits chemoresistance and aggressiveness in esophageal squamous cell carcinoma
by: Aibin Liu, et al.
Published: (2017-06-01) -
RNF219/α‐Catenin/LGALS3 Axis Promotes Hepatocellular Carcinoma Bone Metastasis and Associated Skeletal Complications
by: Shuxia Zhang, et al.
Published: (2021-08-01) -
RNF219/α‐Catenin/LGALS3 Axis Promotes Hepatocellular Carcinoma Bone Metastasis and Associated Skeletal Complications
by: Shuxia Zhang, et al.
Published: (2021-02-01) -
ZNF711 down-regulation promotes CISPLATIN resistance in epithelial ovarian cancer via interacting with JHDM2A and suppressing SLC31A1 expression
by: Geyan Wu, et al.
Published: (2021-09-01)