Transgene regulation using the tetracycline-inducible TetR-KRAB system after AAV-mediated gene transfer in rodents and nonhuman primates.

Transgene regulation using the tetracycline-inducible TetR-KRAB system after AAV-mediated gene transfer in rodents and nonhuman primates.

Numerous studies have demonstrated the efficacy of the Adeno-Associated Virus (AAV)-based gene delivery platform in vivo. The control of transgene expression in many protocols is highly desirable for therapeutic applications and/or safety reasons. To date, the tetracycline and the rapamycin dependen...

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Bibliographic Details
Main Authors: Caroline Le Guiner, Knut Stieger, Alice Toromanoff, Mickaël Guilbaud, Alexandra Mendes-Madeira, Marie Devaux, Lydie Guigand, Yan Cherel, Philippe Moullier, Fabienne Rolling, Oumeya Adjali
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4172479?pdf=render

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http://europepmc.org/articles/PMC4172479?pdf=render

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