Functional Differences Between EBV- and CMV-Specific CD8+ T cells Demonstrate Heterogeneity of T cell Dysfunction in CLL

Functional Differences Between EBV- and CMV-Specific CD8+ T cells Demonstrate Heterogeneity of T cell Dysfunction in CLL

Abstract. Acquired T cell dysfunction is a hallmark of chronic lymphocytic leukemia (CLL), and is linked to an increased risk of infections, but also reduced immune surveillance and disappointing responses to autologous T cell-based immunotherapy. The mechanisms of T cell dysfunction in CLL are not...

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Bibliographic Details
Main Authors: Tom Hofland, Iris de Weerdt, Sanne Endstra, Aldo Jongejan, Laura Platenkamp, Ester B.M. Remmerswaal, Perry D. Moerland, Ineke J.M. ten Berge, Mark-David Levin, Arnon P. Kater, Sanne H. Tonino
Format: Article
Language:English
Published: Wolters Kluwer 2020-04-01
Series:HemaSphere
Online Access:http://journals.lww.com/10.1097/HS9.0000000000000337

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http://journals.lww.com/10.1097/HS9.0000000000000337

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